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Gastroesophageal reflux disease, or GERD, occurs when the lower esophageal sphincter LES ; does not close properly and stomach contents leak back, or reflux, into the esophagus. The LES is a ring of muscle at the bottom of the esophagus that acts like a valve between the esophagus and stomach. The esophagus carries food from the mouth to the stomach. When refluxed stomach acid touches the lining of the esophagus it causes a burning sensation in the chest or throat called heartburn. The fluid may even be tasted in the back of the mouth which is called acid indigestion. Occasional heartburn is common but does not necessarily mean one has GERD. Heartburn that occurs more than twice a week may be considered GERD, and it can eventually lead to more serious health problems. What are the symptoms of GERD? The main symptoms are persistent heartburn and acid regurgitation. Some people have GERD without heartburn. They may experience pain in the chest, hoarseness in the morning, or trouble swallowing. Another symptom may be the feeling food is stuck in the throat or a choking feeling or that the throat is tight. GERD can also cause a dry cough and bad breath. How is GERD treated? If you have had heartburn or any of the other symptoms for a while, you should see your doctor. You may want to visit an internist, a doctor who specializes in internal medicine, or a gastroenterologist, a doctor who treats diseases of the stomach and intestines. Depending on how severe your GERD is, treatment may involve one or more of the following lifestyle changes and medications or surgery. Medications Your doctor may recommend over-the-counter antacids which you can buy without a prescription, or medications that stop acid production or help the muscles that empty your stomach. Antacids, such as Alka-Seltzer, Maalox, Mylanta, Pepto-Bismol, Rolaids, and Riopan, are usually the first drugs recommended to relieve heartburn and other mild GERD symptoms. Many brands on the market use different combinations of three basic salts-magnesium, calcium, and aluminum--with hydroxide or bicarbonate ions to neutralize the acid in your stomach. Antacids, however, have side effects. Magnesium salt can lead to diarrhea, and aluminum salts can cause constipation. Aluminum and magnesium salts are often combined in a single product to balance these effects. Calcium carbonate antacids, such as Tums, Titralac, and Alka-2, can also be a supplemental source of calcium. They may cause constipation as well. Foaming agents, such as Gaviscon, work by covering your stomach contents with foam to prevent reflux. These drugs may help those who have no damage to the esophagus. H2 blockers, such as cimetidine Tagamet HB ; , famotidine Pepcid AC ; , nizatidine Axid AR ; , and ranitidine Zantac 75 ; , impede acid production. They are available in prescription strength and over-the-counter. These drugs provide short-term relief, but over-thecounter H2 blockers should not be used for more than a few weeks at a time. They are effective for about half of those who have GERD symptoms. Many people benefit from taking H2 blockers at bedtime in combination with a proton pump inhibitor. Proton pump inhibitors include omeprazole Prilosec ; , lansoprazole Prevacid ; , pantoprazole Protonix ; , rabeprazole Aciphex ; , and esomeprazole Nexium ; , which are all available by prescription. Proton pump inhibitors are more effective than H2 blockers and can relieve symptoms in almost everyone who has GERD. Another group of drugs, prokinetics, helps strengthen the sphincter and makes the stomach empty faster. This group includes bethanechol Urecholine ; and metoclopramide Reglan ; . Metoclopramide also improves muscle action in the digestive tract, but these drugs have frequent side effects that limit their usefulness. Because drugs work in different ways, combinations of drugs may help control symptoms. People who get heartburn after eating may take both antacids and H2 blockers. The antacids work first to neutralize the acid in the stomach while the H2 blockers act on acid production. By the time the antacid stops working, the H2 blocker will have stopped acid production. Your doctor is the best source of information on how to use medications for GERD.
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